quite generally categorized as lipidic, polymeric and many other types of

nanoconstructs, as illustrated broadly in Fig. 18.9.

18.5.1 Lipid-Based Nanostructured Systems

Table 18.1 delineates a few selected reports from the recent literature on

QbD-enabled development of vesicular and non-vesicular lipid-based drug

nanoconstructs of diverse types.

18.5.1.1 Vesicular Systems

Composed of spherical concentric vesicles with unilamellar, bilamellar multi-

lamellar architectures, liposomes are often prepared from cholesterol and nature-

derived biocompatible phospholipids (Khurana et al. 2017; Sharma et al. 2018).

Owing to their inimitable characteristics, viz., vesicle size, biocompatibility and

amphiphilicity, liposomes are one of the promising carriers used to improve the

therapeutic prospects of drugs at a target site (Akbarzadeh et al. 2013; Rana et al.

2018; Singh et al. 2018a, b). Besides the basic liposomes, some other important

Solid lipid

Liposomes

SLNs

NLCs

Nanoemulsion

CNTs

Polymeric Nanoparticle

Dendrimer

SNEDDs

Fig. 18.9 Various important kinds of lipidic and polymeric drug delivery nanoconstructs

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